RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences
نویسندگان
چکیده
منابع مشابه
Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired b2 integrin function in mice
Integrins are a/b heterodimeric transmembrane receptors that are expressed on all cells. They provide stable adhesion of cells to the extracellular matrix or to other cell counter receptors by forming complex adhesion sites, which serve as signaling platforms (outside-in signaling) that induce cell polarity, migration, survival, and proliferation. Because integrins reside in an inactive state, ...
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The membrane localization and activation of cytoskeletal protein talin are key steps to initiate the integrin transmembrane receptors' activation, which mediates many cellular adhesive responses such as cell migration, spreading and proliferation. RIAM, a membrane anchor and small GTPase RAP1 effector, is known to bind to the C-terminal rod domain of talin (talin-R) and promote localizations of...
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Talin binding to integrin β tails increases ligand binding affinity (activation). Changes in β transmembrane domain (TMD) topology that disrupt α-β TMD interactions are proposed to mediate integrin activation. In this paper, we used membrane-embedded integrin β3 TMDs bearing environmentally sensitive fluorophores at inner or outer membrane water interfaces to monitor talin-induced β3 TMD motion...
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Recycling endosomes feed autophagy B y identifying a protein that hampers membrane traffi cking within the cell, Longatti et al. provide evidence that recycling endosomes supply membrane to growing autophagosomes. When cells are stressed or hungry, they often eat some of their contents through the process of autophagy, in which a membrane compartment called an autophagosome forms and scoops up ...
متن کاملThree Proteins Regulating Integrin Function – Filamin, 14-3-3 and RIAM
Takala, Heikki Three proteins regulating integrin function – filamin, 14-3-3 and RIAM Jyväskylä: University of Jyväskylä, 2011, 78 p. (Jyväskylä Studies in Biological and Environmental Science ISSN 1456-9701; 232) ISBN 978-951-39-4523-7 (nid.) ISBN 978-951-39-4524-4 (PDF) Yhteenveto: Kolme integriinin toimintaa säätelevää proteiinia – filamiini, 14-3-3 ja RIAM Diss. Integrins are transmembrane ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.m807117200